An avian influenza virus H6N1 outbreak in commercial layers: case report and reproduction of the disease.
Identifieur interne : 000020 ( Main/Exploration ); précédent : 000019; suivant : 000021An avian influenza virus H6N1 outbreak in commercial layers: case report and reproduction of the disease.
Auteurs : W J M. Landman [Pays-Bas] ; E A Germeraad [Pays-Bas] ; M J Kense [Pays-Bas]Source :
- Avian pathology : journal of the W.V.P.A [ 1465-3338 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Coquille de l'oeuf (anatomopathologie), Femelle (MeSH), Grippe chez les oiseaux (anatomopathologie), Grippe chez les oiseaux (mortalité), Grippe chez les oiseaux (virologie), Grippe chez les oiseaux (épidémiologie), Maladies de la volaille (anatomopathologie), Maladies de la volaille (mortalité), Maladies de la volaille (virologie), Maladies de la volaille (épidémiologie), Oeufs (MeSH), Pays-Bas (épidémiologie), Poulets (virologie), Virus de la grippe A (pathogénicité), Épidémies de maladies (médecine vétérinaire).
- MESH :
- anatomopathologie : Coquille de l'oeuf, Grippe chez les oiseaux, Maladies de la volaille.
- mortalité : Grippe chez les oiseaux, Maladies de la volaille.
- médecine vétérinaire : Épidémies de maladies.
- pathogénicité : Virus de la grippe A.
- virologie : Grippe chez les oiseaux, Maladies de la volaille, Poulets.
- épidémiologie : Grippe chez les oiseaux, Maladies de la volaille, Pays-Bas.
- Animaux, Femelle, Oeufs.
- Wicri :
- geographic : Pays-Bas.
English descriptors
- KwdEn :
- Animals (MeSH), Chickens (virology), Disease Outbreaks (veterinary), Egg Shell (pathology), Eggs (MeSH), Female (MeSH), Influenza A virus (pathogenicity), Influenza in Birds (epidemiology), Influenza in Birds (mortality), Influenza in Birds (pathology), Influenza in Birds (virology), Netherlands (epidemiology), Poultry Diseases (epidemiology), Poultry Diseases (mortality), Poultry Diseases (pathology), Poultry Diseases (virology).
- MESH :
- geographic , epidemiology : Netherlands.
- epidemiology : Influenza in Birds, Poultry Diseases.
- mortality : Influenza in Birds, Poultry Diseases.
- pathogenicity : Influenza A virus.
- pathology : Egg Shell, Influenza in Birds, Poultry Diseases.
- veterinary : Disease Outbreaks.
- virology : Chickens, Influenza in Birds, Poultry Diseases.
- Animals, Eggs, Female.
Abstract
An outbreak of low pathogenic avian influenza (LPAI) subtype H6N1 (intravenous pathogenicity index = 0.11) infection occurred in four productive brown layer flocks on three farms in the Netherlands within a period of two months. The farms were located at a maximum distance of 4.6 km from each other. The infections were associated with egg production drops up to 74%, pale eggshells and persisting high mortality up to 3.2% per week. Three flocks were slaughtered prematurely as they were not profitable anymore. Newcastle disease, infectious bronchitis, egg drop syndrome and Mycoplasma gallisepticum infections could very likely be excluded as cause of or contributor to the condition in the field. Also, the anticoccidial drug nicarbazin, which can cause egg production drops and eggshell decolouration, was not detected in eggs from affected flocks. Furthermore, post mortem examinations revealed no lesions indicative of bacterial infection. Moreover, bacteriological analysis of hens was negative. The condition was reproduced in commercial brown layers after intratracheal inoculation with virus isolates from affected flocks. It is concluded that the LPAI H6N1 virus is very likely the only cause of the disease. An overview of main manuscripts published since 1976 describing non-H5 and non-H7 avian influenza (AI) virus infections in chickens and their biological significance is included in the present study, in which once more is shown that not only high pathogenic AI virus subtypes H5 and H7 can be detrimental to flocks of productive layers, but also non-H5 and non-H7 LPAI viruses (H6N1 virus). RESEARCH HIGHLIGHTS LPAI H6N1 can be detrimental to productive layers Detrimental effects are severe egg drop and persistent high mortality LPAI H6N1 virus outbreak seems to be self-limiting.
DOI: 10.1080/03079457.2018.1551612
PubMed: 30484684
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Landman</name><affiliation wicri:level="1"><nlm:affiliation>a GD - Animal Health , Deventer , Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>a GD - Animal Health , Deventer </wicri:regionArea><wicri:noRegion>Deventer </wicri:noRegion></affiliation></author><author><name sortKey="Germeraad, E A" sort="Germeraad, E A" uniqKey="Germeraad E" first="E A" last="Germeraad">E A Germeraad</name><affiliation wicri:level="1"><nlm:affiliation>b Department of Virology , Wageningen Bioveterinary Research Lelystad , Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>b Department of Virology , Wageningen Bioveterinary Research Lelystad </wicri:regionArea><wicri:noRegion>Wageningen Bioveterinary Research Lelystad </wicri:noRegion></affiliation></author><author><name sortKey="Kense, M J" sort="Kense, M J" uniqKey="Kense M" first="M J" last="Kense">M J Kense</name><affiliation wicri:level="1"><nlm:affiliation>a GD - Animal Health , Deventer , Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>a GD - Animal Health , Deventer </wicri:regionArea><wicri:noRegion>Deventer </wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30484684</idno><idno type="pmid">30484684</idno><idno type="doi">10.1080/03079457.2018.1551612</idno><idno type="wicri:Area/Main/Corpus">000021</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000021</idno><idno type="wicri:Area/Main/Curation">000021</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000021</idno><idno type="wicri:Area/Main/Exploration">000021</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">An avian influenza virus H6N1 outbreak in commercial layers: case report and reproduction of the disease.</title><author><name sortKey="Landman, W J M" sort="Landman, W J M" uniqKey="Landman W" first="W J M" last="Landman">W J M. 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Animal Health , Deventer </wicri:regionArea><wicri:noRegion>Deventer </wicri:noRegion></affiliation></author></analytic><series><title level="j">Avian pathology : journal of the W.V.P.A</title><idno type="eISSN">1465-3338</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Chickens (virology)</term><term>Disease Outbreaks (veterinary)</term><term>Egg Shell (pathology)</term><term>Eggs (MeSH)</term><term>Female (MeSH)</term><term>Influenza A virus (pathogenicity)</term><term>Influenza in Birds (epidemiology)</term><term>Influenza in Birds (mortality)</term><term>Influenza in Birds (pathology)</term><term>Influenza in Birds (virology)</term><term>Netherlands (epidemiology)</term><term>Poultry Diseases (epidemiology)</term><term>Poultry Diseases (mortality)</term><term>Poultry Diseases (pathology)</term><term>Poultry Diseases (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Coquille de l'oeuf (anatomopathologie)</term><term>Femelle (MeSH)</term><term>Grippe chez les oiseaux (anatomopathologie)</term><term>Grippe chez les oiseaux (mortalité)</term><term>Grippe chez les oiseaux (virologie)</term><term>Grippe chez les oiseaux (épidémiologie)</term><term>Maladies de la volaille (anatomopathologie)</term><term>Maladies de la volaille (mortalité)</term><term>Maladies de la volaille (virologie)</term><term>Maladies de la volaille (épidémiologie)</term><term>Oeufs (MeSH)</term><term>Pays-Bas (épidémiologie)</term><term>Poulets (virologie)</term><term>Virus de la grippe A (pathogénicité)</term><term>Épidémies de maladies (médecine vétérinaire)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Netherlands</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Coquille de l'oeuf</term><term>Grippe chez les oiseaux</term><term>Maladies de la volaille</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza in Birds</term><term>Poultry Diseases</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Influenza in Birds</term><term>Poultry Diseases</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Grippe chez les oiseaux</term><term>Maladies de la volaille</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Épidémies de maladies</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Egg Shell</term><term>Influenza in Birds</term><term>Poultry Diseases</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Disease Outbreaks</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe chez les oiseaux</term><term>Maladies de la volaille</term><term>Poulets</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chickens</term><term>Influenza in Birds</term><term>Poultry Diseases</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe chez les oiseaux</term><term>Maladies de la volaille</term><term>Pays-Bas</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Eggs</term><term>Female</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Oeufs</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Pays-Bas</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An outbreak of low pathogenic avian influenza (LPAI) subtype H6N1 (intravenous pathogenicity index = 0.11) infection occurred in four productive brown layer flocks on three farms in the Netherlands within a period of two months. The farms were located at a maximum distance of 4.6 km from each other. The infections were associated with egg production drops up to 74%, pale eggshells and persisting high mortality up to 3.2% per week. Three flocks were slaughtered prematurely as they were not profitable anymore. Newcastle disease, infectious bronchitis, egg drop syndrome and Mycoplasma gallisepticum infections could very likely be excluded as cause of or contributor to the condition in the field. Also, the anticoccidial drug nicarbazin, which can cause egg production drops and eggshell decolouration, was not detected in eggs from affected flocks. Furthermore, post mortem examinations revealed no lesions indicative of bacterial infection. Moreover, bacteriological analysis of hens was negative. The condition was reproduced in commercial brown layers after intratracheal inoculation with virus isolates from affected flocks. It is concluded that the LPAI H6N1 virus is very likely the only cause of the disease. An overview of main manuscripts published since 1976 describing non-H5 and non-H7 avian influenza (AI) virus infections in chickens and their biological significance is included in the present study, in which once more is shown that not only high pathogenic AI virus subtypes H5 and H7 can be detrimental to flocks of productive layers, but also non-H5 and non-H7 LPAI viruses (H6N1 virus). RESEARCH HIGHLIGHTS LPAI H6N1 can be detrimental to productive layers Detrimental effects are severe egg drop and persistent high mortality LPAI H6N1 virus outbreak seems to be self-limiting.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30484684</PMID><DateCompleted><Year>2019</Year><Month>04</Month><Day>29</Day></DateCompleted><DateRevised><Year>2019</Year><Month>04</Month><Day>29</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1465-3338</ISSN><JournalIssue CitedMedium="Internet"><Volume>48</Volume><Issue>2</Issue><PubDate><Year>2019</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Avian pathology : journal of the W.V.P.A</Title><ISOAbbreviation>Avian Pathol.</ISOAbbreviation></Journal><ArticleTitle>An avian influenza virus H6N1 outbreak in commercial layers: case report and reproduction of the disease.</ArticleTitle><Pagination><MedlinePgn>98-110</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/03079457.2018.1551612</ELocationID><Abstract><AbstractText>An outbreak of low pathogenic avian influenza (LPAI) subtype H6N1 (intravenous pathogenicity index = 0.11) infection occurred in four productive brown layer flocks on three farms in the Netherlands within a period of two months. The farms were located at a maximum distance of 4.6 km from each other. The infections were associated with egg production drops up to 74%, pale eggshells and persisting high mortality up to 3.2% per week. Three flocks were slaughtered prematurely as they were not profitable anymore. Newcastle disease, infectious bronchitis, egg drop syndrome and Mycoplasma gallisepticum infections could very likely be excluded as cause of or contributor to the condition in the field. Also, the anticoccidial drug nicarbazin, which can cause egg production drops and eggshell decolouration, was not detected in eggs from affected flocks. Furthermore, post mortem examinations revealed no lesions indicative of bacterial infection. Moreover, bacteriological analysis of hens was negative. The condition was reproduced in commercial brown layers after intratracheal inoculation with virus isolates from affected flocks. It is concluded that the LPAI H6N1 virus is very likely the only cause of the disease. An overview of main manuscripts published since 1976 describing non-H5 and non-H7 avian influenza (AI) virus infections in chickens and their biological significance is included in the present study, in which once more is shown that not only high pathogenic AI virus subtypes H5 and H7 can be detrimental to flocks of productive layers, but also non-H5 and non-H7 LPAI viruses (H6N1 virus). RESEARCH HIGHLIGHTS LPAI H6N1 can be detrimental to productive layers Detrimental effects are severe egg drop and persistent high mortality LPAI H6N1 virus outbreak seems to be self-limiting.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Landman</LastName><ForeName>W J M</ForeName><Initials>WJM</Initials><AffiliationInfo><Affiliation>a GD - Animal Health , Deventer , Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Germeraad</LastName><ForeName>E A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>b Department of Virology , Wageningen Bioveterinary Research Lelystad , Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kense</LastName><ForeName>M J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>a GD - Animal Health , Deventer , Netherlands.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>12</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Avian Pathol</MedlineTA><NlmUniqueID>8210638</NlmUniqueID><ISSNLinking>0307-9457</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002645" MajorTopicYN="N">Chickens</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004196" MajorTopicYN="N">Disease Outbreaks</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004528" MajorTopicYN="N">Egg Shell</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004531" MajorTopicYN="N">Eggs</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName><QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005585" MajorTopicYN="N">Influenza in Birds</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009426" MajorTopicYN="N" Type="Geographic">Netherlands</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011201" MajorTopicYN="N">Poultry Diseases</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Avian influenza virus</Keyword><Keyword MajorTopicYN="N">H6N1</Keyword><Keyword MajorTopicYN="N">LPAI</Keyword><Keyword MajorTopicYN="N">egg production</Keyword><Keyword MajorTopicYN="N">layers</Keyword><Keyword MajorTopicYN="N">mortality</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>11</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>4</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>11</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30484684</ArticleId><ArticleId IdType="doi">10.1080/03079457.2018.1551612</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Pays-Bas</li></country></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Landman, W J M" sort="Landman, W J M" uniqKey="Landman W" first="W J M" last="Landman">W J M. Landman</name></noRegion><name sortKey="Germeraad, E A" sort="Germeraad, E A" uniqKey="Germeraad E" first="E A" last="Germeraad">E A Germeraad</name><name sortKey="Kense, M J" sort="Kense, M J" uniqKey="Kense M" first="M J" last="Kense">M J Kense</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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